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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Bioorg Med Chem. 2014 Jun 16;22(15):3971–3981. doi: 10.1016/j.bmc.2014.06.004

Figure 9.

Figure 9

Dose-dependent competition of zinc-chelating, active site inhibitors with BQ

(A) Impact of AdH on initial rates of BoNT/A LC (B) Impact of AdH on kobs of BQ inactivation (C) Impact of 28 on initial rates of BoNT/A LC (D) Impact of 28 on kobs of BQ inactivation. Active site inhibitors AdH and 28 compete with BQ covalent inactivation.