Table 4.
DXA-derived measurements of female participants on ART
| Variable |
Lipoatrophy* |
P-value** |
Lipohypertrophy*** |
P-value** | ||
|---|---|---|---|---|---|---|
| With n = 29 Median [IQR] | Without n = 143 Median [IQR] | With n = 46 Median [IQR] | Without n = 126 Median [IQR] | |||
|
DXA-derived measures |
|
|
|
|
|
|
| Arm fat (%) |
37.4 [30.8-44.1] |
38.3 [31.8-47.1] |
0.380 |
39.8 [31.5-48.3] |
38.1 [31.7-45.1] |
0.319 |
| Lower limb fat (%) |
37.6 [31.5-40.6] |
43.4 [36.6-49.7] |
0.001 |
39.2 [33.3-49.7] |
41.8 [36.3-48.8] |
0.761 |
| Trunk fat (%) |
34.7 [29.9-38.0] |
35.1 [27.9-43.1] |
0.719 |
37.9 [30.7-45.3] |
34.4 [26.6-40.4] |
0.019 |
| Lower limb fat/ht (%) |
23.6 [19.7-25.4] |
27.4 [23.4-31.5] |
0.001 |
25.4 [21.9-31.1] |
26.5 [23.2-29.7] |
0.631 |
| Total limb fat/ht (%) |
22.7 [20.8-27.0] |
25.4 [22.0-29.9] |
0.015 |
25.4 [20.8-31.1] |
25.2 [21.8-29.1] |
0.825 |
| Lower limb fat/BMI (%) |
1.3 [1.2-1.7] |
1.6 [1.3-1.8] |
0.049 |
1.4 [1.2-1.6] |
1.6 [1.3-1.8] |
0.019 |
| Total limb fat/BMI (%) |
1.3 [1.3-1.6] |
1.5 [1.3-1.6] |
0.193 |
1.3 [1.2-1.5] |
1.5 [1.3-1.7] |
0.006 |
| Trunk fat/lower limb fat (%) |
0.94 [0.76-1.15] |
0.83 [0.66-0.96] |
0.017 |
0.93 [0.80-1.10] |
0.81 [0.66-0.94] |
0.003 |
| Trunk fat/ total limb fat (%) | 1.0 [0.8-1.0] | 0.9 [0.7-1.0] | 0.045 | 0.93 [0.85-1.03] | 0.85 [0.72-0.97] | 0.003 |
*based on patient report, those with moderate or severe fat loss in 2 or more regions.
**Wilcoxon Rank-sum (Mann–Whitney) tests for continuous variables and chi-square tests for binary variables.
***based on patient report, those with moderate or severe fat gain in 2 or more regions.