Fig. 4.

Cross-talk between micro-RNA patterns obtained in surgical and stereotactic body radiotherapy (SBRT) cohorts. a Only 3 overlapping micro-RNAs were identified in the surgical and SBRT cohorts (miR-328, miR-502-5p and miR-199b-5p (Table 1). b Unsupervised clustering of patients in the surgical and SBRT cohorts based on differentially expressed micro-RNAs successfully segregated patients with oligo-and polymetastatic disease independently on clinical parameters of disease progression (heat maps represent normalized CT values; green are up- and red are down-regulated micro-RNAs). c Application of the SBRT micro-RNA signature to surgical patients successfully separated them into oligo-and polymetastatic clusters (left panel); the same was true for application of the surgery micro-RNA signature to SBRT cohort