Table 1.
Known functions and down-stream targets of oligomiRs detected in clinical databases of oligometastatic patients
| miRNA | Dataset | Oncomir or suppressor | Controlled biological processes | Down-stream targets | References |
|---|---|---|---|---|---|
| Mir-655 | Surgery | Suppressor | EMT | TGFBR2,ZEB1 | [88] |
| mir-154 | Surgery | Suppressor | Proliferation, motility, cell cycle, EMT | TLR2, HMGA2, CCND2 | [89–91] |
| mir-329 | Surgery | Suppressor | Proliferation | E2F1 | [84] |
| mir-330 | Surgery | Mixed | Proliferation, invasion, cell cycle, adhesion, apoptosis | SP1, CDC42, SH3GL2 | [92, 93] |
| mir-485 | Surgery | Suppressor | Proliferation, migration | MAT1A | [76] |
| mir-380 | Surgery | Oncomir | Proliferation, cell cycle | p53 | [94] |
| mir-298 | Surgery | Suppressor | Drug sensitivity | P-gp | [95] |
| mir-153 | Surgery | Mixed | Proliferation, apoptosis, drug resistance | PTEN, FOXO3a, FOXO1 | [96–98] |
| mir-296 | Surgery | Mixed | Proliferation, cell cycle, apoptosis, drug resistance, angiogenesis | ICAM1, CDX1, EAG1, Scrib, HMGA1, HGS | [99–102] |
| mir-448 | Surgery | Suppressor | EMT | SATB1 | [103] |
| mir-133a | Surgery | Suppressor | Invasion, proliferation | FSCN1, PNP, TALGN2 | [104–106] |
| mir-328 | Both | Suppressor | Invasion, drug resistance, cytokinesis, migration, cell cycle, proliferation, ECM degradation | ABCG2, MMP16, KIF23, PTPRJ | [78, 107–110] |
| mir-502 | Both | Suppressor | Proliferation, cell cycle | Rab1B | [85] |
| miR-199b-5p | Both | Suppressor | Proliferation, drug resistance, invasion | HER2, HES1 | [111–113] |
| miR-125a-3p | SBRT | Suppressor | Invasion, proliferation, apoptosis, cell cycle arrest | FYN, RHOA, BCL2, ALDH1A3, MCLl1, VEGF, MMP11, TNFAIP3 | [74, 79, 114–118] |
| miR-140-5p | SBRT | Suppressor | EMT, proliferation | TGFBR1, FGF9 | [119] |
| miR-29c-3p | SBRT | Suppressor | Proliferation, invasion, adhesion, angiogenesis, drug resistance, apoptosis, cell cycle arrest | MMP2, ITGB1, SIRT1, TIAM1, TNFAIP3, CCNE1, p85, CDC42 | [80, 120–124] |
| miR-489 | SBRT | Suppressor | Proliferation | PTPN11 | [125] |
| miR-331-5p | SBRT | Suppressor | Cell cycle | E2F1 | [83] |
| miR-193a-3p | SBRT | Suppressor | Apoptosis, proliferation, EMT, drug resistance, cell cycle | MCL1, EGFR, PLAU, KRAS, p73, E2F6 | [82, 126–129] |
| miR-363-3p | SBRT | Mixed | EMT, invasion, proliferation | MBP1, PDPN | [75, 130, 131] |
Functions that are up-regulated by a micro-RNA are italicized