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Metabolic pathway of prostaglandins via cyclooxygenase. Arachidonic acid is released from membrane phospholipids by phospholipase A2 and converted to PGG2 and subsequently PGH2 by COX. PGH2 is then converted to PGI2, TXA2, PGD2, and PGE2. cPLA2: Cytosolic phospholipase A2; COX: Cyclooxygenase; PG: Prostaglandin; TX: Thromboxane.
