Figure 11.

Meta-analysis of PP13 in predicting preterm preeclampsia in the third trimester. (A) Forest plot analysis was performed including seven studies based on unaffected and preterm preeclampsia cases. The detection rate (DR) at 10% False Positive Rate (FPR) of cases of preterm preeclampsia is shown in case-control and prospective cohort studies using all-comers. The DR was extracted from Receiver Operation Characteristics (ROC) curves based on the adjusted multiple of the medians (MoMs) of PP13. The final analysis took into consideration the total study size and the size of the preeclampsia group. Number 1 on the study list reflects the results of the meta-analysis depicted with a dark filled diamond compared to individual studies depicted with blue diamonds. The relative weight of a certain study in the analysis is reflected by the relative size of the diamonds. (B) The table lists studies used to perform the Forest plot for the meta-analysis of cases of preterm preeclampsia <37 weeks), including early onset preeclampsia (<34 weeks). Weight represents the relative impact of the study in the meta-analysis. DR for 10% FPR is shown along with the 95% confidence interval (95% CI). The Likelihood ratio (LR) was calculated for positive LR [sensitivity/(1-specificity)], negative LR [(1-sensitivity)/specificity] and overall LR (positive LR/negative LR). For the meta-analysis, the values were adjusted to the relative weight of each study in the meta-analysis. The numbers on the left side correspond to the graph numbers in (A). PE, preeclampsia; GA, gestational age in weeks.