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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: J Comput Aided Mol Des. 2014 Jun 24;28(7):765–778. doi: 10.1007/s10822-014-9758-7

Figure 7.

Figure 7

(A) Kinetic analysis of inhibitor C1 using CFP-(141-206)-YFP and BoNT/A 1-448. DTT was included in the assay buffer. Global fits (using all points) to models for competitive and non-competitive inhibition were compared. The data was best fit to the model describing non-competitive inhibition. (B) Kinetic analysis of inhibitor C2 using CFP-(141-206)-YFP and BoNT/A 1-448 in the absence of reducing agents. (C) Predicted binding model of inhibitor C1 bound at the α-exosite. (D) Predicted binding model of inhibitor C2 bound at the β-exosite.