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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Mol Cell Neurosci. 2014 Jun 28;61:187–200. doi: 10.1016/j.mcn.2014.06.008

Table 3. GO analysis of biological pathways dysregulated by knockdown of Kdm6b.

The top 100 genes showing reduced induction in neurons infected with Kdm6b shRNA compared to control were subjected to gene ontology (GO) analysis using DAVID.

Enrichment score 4.57
Biological process Gene count P value Benjamini FDR Genes
Response to wounding 13 5.26E-07 0.0004 0.0008 NOG, SPHK1, PPARG, TAC1, CCL4, CCL7, TNFRSF1B, PROCR, F3, HBEGF, KDM6B, CD14, FN1
Inflammatory response 9 3.93E-05 0.0167 0.0609 TNFRSF1B, SPHK1, PPARG, TAC1, CCL4, KDM6B, CCL7, CD14, FN1
Defense response 10 9.39E-04 0.2347 1.4444 TNFRSF1B, SPHK1, PPARG, TAC1, CCL4, KDM6B, CD74, CCL7, CD14, FN1
Immune response 10 0.0013 0.2479 2.0442 RNF125, ICAM1, TNFRSF1B, PROCR, IL4RA, TNFSF9, CCL4, CD74, CCL7, CD14

The top functional annotation cluster is shown. Significant pathways are highlighted in gray.