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. 2014 Jun 10;155(9):3302–3314. doi: 10.1210/en.2014-1112

Figure 1.

Figure 1.

High-fat diet feeding for 20 weeks increases body weight and fat mass leading to diet-induced obesity (DIO), elevated plasma glucose, insulin, and IGF1 levels. A, Body weight over 20 weeks in mice fed low-fat chow (control) or high-fat diet to induce DIO. B, Body composition of control vs DIO mice measured by magnetic resonance imaging after 20 weeks on diet. C–E, Circulating plasma concentrations of (C) glucose, (D) insulin, and (E) insulin-like growth factor 1 (IGF1). F, qRT-PCR measured Igf1 mRNA from jejunum. Data expressed as mean ± SEM. *, P < .05 DIO vs control, repeated measures ANOVA (A) or unpaired t test (B–F), n ≥ 5.