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Mean weekly body weights of female (A) and male (B) mice during 14 weeks of ad libitum feeding of either chow (control diet) or high-fat/high-sucrose (HF) diet. Absolute fat mass in female (C) and male (D) WT and RIIαKO mice on control and HF diets as determined by magnetic resonance imaging. Female RIIαKO and WT mice (E) and livers counterstained with Oil Red O and hematoxylin and eosin (F) after 14 weeks of HF diet feeding Oil Red O. Values are mean ± SEM. *, P < .05.
