Table 2.
Serum Parameters in RIIαKO and WT Mice After 14 Weeks of CD or HFD Feeding Period in Nonfasted Mice
| BW, g | FFA, mM | TG, mg/dL | Glucose, mg/dL | Cholesterol, mg/dL | Insulin, ng/mL | Leptin, ng/mL | |
|---|---|---|---|---|---|---|---|
| Females | |||||||
| CD | |||||||
| Wild type (n = 7) | 24.35 ± 1.41 | 0.71 ± 0.23 | 119.09 ± 30.57 | 140.00 ± 16.23 | 87.25 ± 9.74 | 0.86 ± 0.38 | 4.64 ± 1.08 |
| Mutant (n = 8) | 23.38 ± 0.70 | 0.50 ± 0.09 | 119.14 ± 11.75 | 154.50 ± 37.98 | 108.29 ± 6.91 | 0.99 ± 0.29 | 5.03 ± 0.52 |
| HFD | |||||||
| Wild type (n = 10) | 44.94 ± 2.10 | 0.88 ± 0.2 | 153.82 ± 31.53 | 306.14 ± 48.84 | 204.89 ± 25.71 | 3.77 ± 0.64 | 131.28 ± 30.45 |
| Mutant (n = 8) | 34.88 ± 2.86 | 0.73 ± 0.09 | 133.25 ± 8.53 | 248.63 ± 44.66 | 172.44 ± 8.70 | 2.84 ± 0.87 | 75.42 ± 15.46 |
| HFD, P = .011; CD, P = .76a | P = .26 | P = .91 | HFD, P = .022; CD, P = .93a | P = 1.0 | P = .70 | P = .70 | |
| Males | |||||||
| CD | |||||||
| Wild type (n = 4) | 31.48 ± 2.14 | 0.70 ± 0.19 | 142.68 ± 27.99 | 131.50 ± 27.08 | 125.87 ± 12.88 | 1.33 ± 0.49 | 15.63 ± 3.62 |
| Mutant (n = 9) | 29.25 ± 1.20 | 0.54 ± 0.08 | 122.45 ± 26.80 | 158.50 ± 26.58 | 122.75 ± 3.72 | 0.77 ± 0.06 | 5.53 ± 2.35 |
| HFD | |||||||
| Wild type (n = 7) | 47273 ± 1.01 | 0.64 ± 0.14 | 230.48 ± 46.13 | 273.17 ± 81.78 | 209.00 ± 14.08 | 9.03 ± 2.64 | 87.75 ± 18.35 |
| Mutant (n = 6) | 44.41 ± 2.20 | 0.52 ± 0.06 | 164.34 ± 22.15 | 273.43 ± 40.36 | 202.75 ± 22.49 | 2.25 ± 0.32 | 63.65 ± 10.23 |
| P = .21 | P = .35 | P = .32 | P = 1.0 | P = .41 | P = .023 | P = .34 |
Abbreviations: BW, body weight; FFA, free fatty acids; TG, triacylglycerols. Values are mean ± SEM. P values are from multivariable ANCOVA comparing genotype adjusted for covariates (BW, diet).
a
Reported separately for each diet due to statistically significant interaction with genotype.