Table 5.
PKA Activity in Gonadal AT of WT and RIIαKO Mice After 14 Weeks of ad Libitum Feeding With CD or HFD
| PKA Activity |
|||
|---|---|---|---|
| −cAMP | +cAMP | Ratio | |
| CD | |||
| WT (n = 7) | 39.94 ± 8.55 | 358.36 ± 67.65 | 0.11 ± 0.01 |
| Mutant (n = 7) | 42.87 ± 3.00 | 296.69 ± 23.86 | 0.15 ± 0.01 |
| HFD | |||
| WT (n = 8) | 31.24 ± 5.03 | 414.45 ± 41.42 | 0.08 ± 0.01 |
| Mutant (n = 7) | 62.31 ± 12.82 | 539.16 ± 90.31 | 0.11 ± 0.01 |
| P = .047a | P = .58 | P = .001 | |
−cAMP activity (basal) was without and +cAMP activity was activity with 5 μmol added cAMP. Data for female mice are shown. P values derive from multivariable ANCOVA adjusting for diet; values are mean ± SEM.
a
Overall model was not statistically significant.