Table 7.
PKA Activity in Liver of WT and RIIαKO Mice After 14 Weeks of ad Libitum Feeding With CD or HFD
| PKA Activity |
|||
|---|---|---|---|
| −cAMP | +cAMP | Ratio | |
| CS | |||
| WT (n = 8) | 860.09 ± 140.47 | 2803.01 ± 372.60 | 0.37 ± 0.08 |
| Mutant (n = 8) | 694.53 ± 261.32 | 1752.96 ± 724.79 | 0.77 ± 0.21 |
| HFD | |||
| WT (n = 8) | 1221.54 ± 412.92 | 2853.38 ± 441.15 | 0.43 ± 0.14 |
| Mutant (n = 7) | 483.35 ± 188.37 | 715.17 ± 306.70 | 1.17 ± 0.49 |
| P = .12 | P = .003 | P = .030a | |
−cAMP activity (basal) was activity without and +cAMP activity (total) was activity with 5 μmol added cAMP; ratio was the ratio of basal to total PKA activity. Data shown are for female mice. P values derive from multivariable ANCOVA adjusting for diet; values are mean ± SEM.
a
Overall model was not statistically significant.