Table 2.
Summary of IC50 values and maximal inhibitions of SMase inhibitors
| Compound ID | Natural substrate (pH 6.5) |
Natural substrate (pH 5.0) |
HMU-PC substrate (pH 5.0) |
|||
|---|---|---|---|---|---|---|
| IC50 (μM) |
Maximal resp. |
IC50 (μM) |
Maximal resp. |
IC50 (μM) |
Maximal resp. |
|
| MLS000737788 | 1.7 | 104.2 | 9.5 | 94.3 | 0.27 | 101.9 |
| MLS000574110 | 2.4 | 84.8 | 1.7 | 79.1 | 15.1 | 82.1 |
| MLS000707545 | 2.9 | 77.2 | 2.3 | 72.0 | 17.1 | 93.4 |
| MLS001164567 | 3.2 | 100.7 | 4.2 | 97.8 | n.a. | 15.8 |
| MLS000097140 | 3.3 | 82.7 | 5.0 | 81.7 | n.a. | 6.2 |
| MLS000720877 | 5.6 | 61.6 | 5.7 | 31.1 | 0.10 | 99.2 |
| MLS000950682 | 33.1 | 71.2 | 6.4 | 43.4 | 3.5 | 79.0 |
| MLS000097294 | 38.2 | 104.4 | 25.1 | 103.2 | 5.3 | 99.1 |
| MLS002248315 | n.a. | 8.6 | n.a. | 0.8 | 0.99 | 31.4 |
| MLS001164606 | n.a. | 26.8 | n.a. | 9.1 | 1.5 | 51.8 |
Resp. response, n.a. not active (maximal response is under 30%)