Fig. 2.

Hemispheric 3D maps of significant negative associations between 1-year and 2-year change in VV and baseline cortical gray matter thickness in AD (1-year: N=142; 2-year N: 109), MCI (1-year: N=335; 2-year N: 251), and healthy elderly individuals (1-year: N=200; 2-year N: 176), after controlling for age and sex (AD: 1-year change, left: −log₁₀(p-values)=2.39–4.64, right: −log₁₀(p-values)=3.04–5.03, 2-year change, left: −log₁₀(p-values)=2.95–5.20, right: −log₁₀(p-values)=3.64–5.90; MCI: 1-year change, left: −log₁₀(p-values)=1.58–3.84, right: −log₁₀(p-values)=3.28–5.54, 2-year change, left: −log₁₀(p-values)=1.55–3.81, right: −log₁₀(p-values)= 1.55–3.80; Controls: 1-year change, left: −log₁₀(p-values)=1.98–4.24, right: −log₁₀(p-values)=2.36–4.62, 2-year change, left: −log₁₀(p-values)=3.42–5.68, right: −log₁₀(p-values)=3.32–5.58, corrected). Results were corrected for multiple comparisons by thresholding at a q=0.05 false discovery rate (FDR) threshold across the entire brain surface. Blue represents areas where p-values passed the corrected significance threshold for a negative relationship between ventricular enlargement and cortical thickness values (greater VV enlargement associated with lower cortical GM thickness at baseline).