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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Behav Brain Res. 2014 Jul 12;272:286–302. doi: 10.1016/j.bbr.2014.07.012

Tab. 1.

BLOCK models for the placebo and CONC models for the sedative groups.

BLOCK/CONC MODEL PEAK VELOCITY [eq. 1] (n=60)
Group CPKV Average 1/unit CPKV ±SD 1/unit CPKV Range 1/unit CPKV >0/<0/~0 # t-value Prob R2 Average R2 ±SD R2 Range
Placebo (Blocks) −0.002 0.015 −0.047
0.028		 14/19/27 −1.2 0.2 0.76 0.13 0.36
0.97
Propof. (μg/ml) −0.33* 0.24 −0.91
0.22		 1/56/3 −10.3 1×10−14 0.72 0.18 0.27
0.97
Midaz. (ng/ml) −0.0050* 0.0048 −0.0199
0.0060		 0/49/11 −8.0 6×10−11 0.65 0.18 0.27
0.93
Dexmed. (ng/ml) −0.21* 0.33 −0.96
0.79		 6/39/15 −4.9 8×10−6 0.68 0.16 0.38
0.94
BLOCK/CONC MODEL DURATION [eq. 2] (n=60)
Group CDUR Average 1/unit CDUR ±SD 1/unit CDUR Range 1/unit CDUR >0/<0/~0 # t-value Prob R2 Average R2 ±SD R2 Range
Placebo (Blocks) 0.004 0.020 −0.050
0.048		 25/8/27 1.7 0.09 0.62 0.28 0.04
0.98
Propof. (μg/ml) 1.82* 4.10 −0.44
25.71		 49/2/9 3.4 1×10−3 0.50 0.25 0.05
0.89
Midaz. (ng/ml) 0.029* 0.041 −0.005
0.186		 54/0/6 5.4 1×10−6 0.42 0.20 0.09
0.86
Dexmed. (ng/ml) 1.08* 1.27 −0.17
6.48		 45/2/13 6.6 1×10−8 0.44 0.21 0.07
0.86
BLOCK/CONC MODEL RECIPROCAL OF LATENCY [eq. 3] (n=60)
Group CRLAT Average 1/unit CRLAT ±SD 1/unit CRLAT Range 1/unit CRLAT >0/<0/~0 # t-value Prob R2 Average R2 ±SD R2 Range
Placebo (Blocks) 0.015* 0.015 −0.020
0.054		 41/3/16 7.9 8×10−11 0.14 0.10 0.00
0.41
Propof. (μg/ml) −0.27* 0.21 −0.63
0.21		 4/46/10 −9.8 6×10−14 0.23 0.16 0.00
0.63
Midaz. (ng/ml) −0.0041* 0.0040 −0.0170
0.0038		 0/46/14 −8.0 5×10−11 0.16 0.11 0.00
0.45
Dexmed. (ng/ml) −0.03 0.27 −0.86
0.78		 12/21/27 −0.9 0.3 0.12 0.09 0.00
0.45
BLOCK/CONC MODEL GAIN PRIMARY SACCADE [eq. 4] (n=60)
Group CGAIN Average 1/unit CGAIN ±SD 1/unit CGAIN Range 1/unit CGAIN >0/<0/~0 # t-value Prob R2 Average R2 ±SD R2 Range
Placebo (Blocks) 0.006* 0.015 −0.026
0.049		 25/8/27 3.1 0.003 0.21 0.15 0.00
0.62
Propof. (μg/ml) −0.18* 0.20 −0.79
0.18		 4/40/16 −6.9 4×10−9 0.23 0.17 0.00
0.76
Midaz. (ng/ml) −0.0045* 0.0036 −0.0124
0.0086		 1/50/9 −9.7 8×10−14 0.27 0.16 0.00
0.70
Dexmed. (ng/ml) 0.04 0.25 −0.43
0.62		 14/14/32 1.1 0.3 0.18 0.14 0.01
0.55

“C[] Average”: average of the parameter C from eqs. [1–4] (±SD and range). The unit is reported in parenthesis in the first column below the group label. An asterisk near the average indicates that the value was significantly different from 0, using a one-sample t-test with H0=0 (p<0.05, n=60). The t-value and probability of these tests are reported in columns “t-value” and “Prob”. The “>0/<0/~0” columns report the number of >0 significances, the number of <0 significances, and the number of no significances (~0) of the C values at the subject level. Last three columns: average, ±SD and range of the R2 of the model fits.