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. 2014 Aug 5;2014:507905. doi: 10.1155/2014/507905

(a).

Source Year Transplants Recipients
Species Strain Tissue used Species Strain Location
Nicholas et al. [40] 1987 Mice BALB/cANC Embryonic neocortex
These cells do not express MHC I.
Mice BALB/cANC
6–8-week-old female mice
Right lateral ventricle
CBA/J
E15–18
Results
Significantly more inflammatory cells in allogeneic than in syngeneic grafts. There were some T cells in the allogeneic grafts, but not syngeneic grafts. More neurons survive in syngeneic versus allogeneic grafts. There is less necrosis as well.

Lawrence et al. [41] 1990 Rat PVG Embryonic hippocamus rat AO Hippocampus
AO (E18–20)-no MHC I
Results
Allografts were rejected by both macrophages and cytotoxic T cells. Grafts were infiltrated early (3–6 d) by host microglia especially in necrotic tissue surrounding the graft. Blood vessels begin to join the graft to the host as early as 1 day. Lymphocytes, macrophages, and microglia begin to accumulate around the larger vessels. MHC I expression is turned on 3–6 days after transplanting. Most cells in the allografts were rejected by cytotoxic T cells by 27 d.