(a).
| Source | Year | Transplants | Recipients | ||||
|---|---|---|---|---|---|---|---|
| Species | Strain | Tissue used | Species | Strain | Location | ||
| Nicholas et al. [40] | 1987 | Mice | BALB/cANC | Embryonic neocortex These cells do not express MHC I. |
Mice | BALB/cANC 6–8-week-old female mice |
Right lateral ventricle |
| CBA/J | |||||||
| E15–18 | |||||||
| Results | |||||||
| Significantly more inflammatory cells in allogeneic than in syngeneic grafts. There were some T cells in the allogeneic grafts, but not syngeneic grafts. More neurons survive in syngeneic versus allogeneic grafts. There is less necrosis as well. | |||||||
|
| |||||||
| Lawrence et al. [41] | 1990 | Rat | PVG | Embryonic hippocamus | rat | AO | Hippocampus |
| AO | (E18–20)-no MHC I | ||||||
| Results | |||||||
| Allografts were rejected by both macrophages and cytotoxic T cells. Grafts were infiltrated early (3–6 d) by host microglia especially in necrotic tissue surrounding the graft. Blood vessels begin to join the graft to the host as early as 1 day. Lymphocytes, macrophages, and microglia begin to accumulate around the larger vessels. MHC I expression is turned on 3–6 days after transplanting. Most cells in the allografts were rejected by cytotoxic T cells by 27 d. | |||||||