Figure 1.

The influence of the AAPs aripiprazole (a), risperidone (b), and amisulpride (c) and negative control treatments lorazepam (d), modafinil (e), and valproate (f) on sensory gating, expressed as percent P50 suppression. All AAPs significantly increased P50 suppression in low-gating healthy volunteers. Lorazepam and modafinil reduced percent P50 suppression independently of low- and high-gating subgroups. Differences in placebo gating within one cohort originate from the exclusion of invalid data sets in a nonpairwise manner. *Significant difference between active drug and placebo. Error bars refer to SEM.