Table 2. Startle and P50 Amplitudes, and Habituation of Low- and High-Gating Groups Receiving Treatment with Placebo and Active Drug.
|
Study cohort 1 |
Study cohort 2 |
Study cohort 3 |
||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Placebo |
Aripiprazole |
Risperidone |
Placebo |
Amisulpride |
Lorazepam |
Placebo |
Modafinil |
Valproate |
||||||||||
| Group | Low | High | Low | High | Low | High | Low | High | Low | High | Low | High | Low | High | Low | High | Low | High |
| n (PPI, P50) | 14, 14 | 14, 14 | 11, 13 | 13, 14 | 11, 12 | 13, 14 | 15, 15 | 15, 14 | 15, 14 | 15, 14 | 12, 13 | 13, 11 | 15, 15 | 14, 15 | 15, 14 | 13, 14 | 14, 14 | 14, 14 |
| Startle amplitude (μV)a | ||||||||||||||||||
| Block 1 | 4.45 (0.25) | 5.04 (0.14) | 4.69 (0.24) | 4.72 (0.29) | 4.27 (0.27) | 4.81 (0.15) | 4.85 (0.18) | 4.57 (0.18) | 4.86 (0.22) | 4.74 (0.14) | 4.73 (0.23) | 4.17 (0.23) | 4.82 (0.16) | 4.36 (0.19) | 4.96 (0.15) | 4.41 (0.20) | 4.94 (0.17) | 4.48 (0.26) |
| Block 2 | 3.79 (0.25) | 4.58 (0.18) | 4.27 (0.29) | 4.47 (0.24) | 3.52 (0.30) | 4.21 (0.21) | 4.52 (0.22) | 4.18 (0.15) | 4.36 (0.27) | 4.10 (0.13) | 4.05 (0.22) | 3.77 (0.20) | 4.44 (0.17) | 4.10 (0.21) | 4.64 (0.16) | 4.06 (0.21) | 4.57 (0.16) | 4.16 (0.23) |
| Block 3 | 3.57 (0.25) | 4.27 (0.20) | 3.51 (0.32) | 4.22 (0.17) | 3.19 (0.38) | 3.76 (0.27) | 4.21 (0.31) | 3.77 (0.20) | 4.24 (0.26) | 3.75 (0.22) | 3.63 (0.29) | 3.04 (0.35) | 4.27 (0.19) | 3.71 (0.20) | 4.46 (0.18) | 3.87 (0.23) | 4.45 (0.18) | 3.78 (0.18) |
| Habituation (%) | 19.78 (39.61) | 10.64 (57.19) | 19.22 (32.19) | 48.15 (17.55) | 22.01 (40.60) | 16.20 (42.87) | 22.65 (45.58) | 18.11 (35.71) | 13.46 (54.71) | 3.63 (33.03) | 37.14 (43.10) | 31.84 (36.39) | 29.87 (28.58) | 12.31 (27.97) | 12.44 (30.12) | 11.90 (27.90) | 28.41 (24.62) | 8.54 (23.89) |
| P50 amplitudes (μV)b | ||||||||||||||||||
| S1 | 1.25 (0.08) | 1.35 (0.09) | 1.34 (0.08) | 1.31 (0.08) | 1.20 (0.06) | 1.29 (0.08) | 1.89 (0.08) | 1.29 (0.09) | 1.27 (0.11) | 1.32 (0.08) | 1.05 (0.07) | 1.03 (0.10) | 1.31 (0.11) | 1.17 (0.07) | 1.25 (0.11) | 1.30 (0.11) | 1.30 (0.14) | 1.25 (0.08) |
| S2 | 1.10 (0.07) | 0.61 (0.08) | 0.86 (0.12) | 0.65 (0.12) | 0.82 (0.09) | 0.78 (0.10) | 1.00 (0.07) | 0.65 (0.07) | 0.89 (0.12) | 0.71 (0.09) | 0.88 (0.08) | 0.76 (0.06) | 0.98 (0.07) | 0.44 (0.06) | 0.96 (0.07) | 0.75 (0.07) | 0.80 (0.08) | 0.61 (0.09) |
a
ln-transformed.
b
Sqrt-transformed, SD values are shown in brackets.