Table 2. Comparisons of CSF Biomarker Concentrations Between Bipolar Disorder Patients and Healthy Controls (Linear Regression with Age and Gender as Covariates).
| Biomarker |
Controls (N=86a) |
Bipolar disorder (N=133) |
Analysis |
|||||
|---|---|---|---|---|---|---|---|---|
| Meanb | SE | Meanb | SE | β | t | d.f. | P | |
| NF-L (pg/ml)c | 359 | 34 | 480 | 25 | 0.155 | 3.269 | 1 | 0.001 |
| MBP (pg/ml) | 508 | 19 | 553 | 15 | 0.094 | 1.835 | 1 | 0.068 |
| S100B (pg/ml) | 850 | 23 | 873 | 19 | 0.047 | 0.754 | 1 | 0.452 |
| H-FABP (pg/ml) | 409 | 21 | 453 | 17 | 0.097 | 1.605 | 1 | 0.110 |
Abbreviations: NF-L, neurofilament light chain; MBP, myelin basic protein; S100B, calcium-binding protein S100B; h-FABP, heart-type fatty acid binding protein.
a
N=71 for NF-L.
b
Estimated marginal means adjusted for age and gender (H-FABP: only adjusted for age).
c
Log transformed before statistical analysis.