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. 2014 May 7;39(10):2376–2386. doi: 10.1038/npp.2014.85

Figure 1.

Figure 1

Significant reductions in mGluR5 expression in the nucleus accumbens following CORT exposure (7 days). (a) Following CORT exposure (7 days) a significant reduction in mGluR5 immunoreactivity (IR) is evident in the core, but not the shell of the nucleus accumbens. No change in mGluR5 IR in the dorsomedial (DM) caudate putamen was observed (CPu). (b, c) Representative photomicrographs ( × 40) showing cytological expression of mGlu5 receptors in the core for the Water and CORT groups. Arrows identify areas of dense mGlu5 receptor immunoreactivity. Scale bar represents 50 microns. (d) Decreased mGluR5 dimer protein expression (250 kDa) was observed in the nucleus accumbens core as confirmed by western blot analysis following CORT exposure (7 days). Monomer (130 kDa) expression was unaltered. (e) Representative western blots showing decreased mGluR5 expression in the mGluR5 dimer (right) in the CORT group. *Signifies differences from Water. Values on graphs represent mean±SEM.