Figure 3.

Positive allosteric modulation of mGluR5 does not alter the interoceptive effects of alcohol. (a) Pretreatment with CDPPB a positive allosteric modulator of mGluR5 administered IP did not alter the discriminative stimulus effects of alcohol, but (b) produced an overall reduction in response rate. These graphs represent the data from two separate assessments in which one group of rats was tested on 0, 1, 10 mg/kg CDPPB (n=13) and the other was tested on 0, 20, 40 mg/kg (n=7). Therefore, the data points for the vehicle condition on the graph represent a combination of the two groups (n=20). Data from the two groups were analyzed separately but are graphically depicted together for ease of presentation. Horizontal dashed line (>80%) represents full expression of the discriminative stimulus effects of alcohol. Values on graphs represent mean±SEM.