Figure 3.

Normalized frequency of DA transients (+SEM) over time for 10-s epochs surrounding individual lever press actions (indicated by dotted vertical line) during CS+ (filled) and CS− (open) trials for saline- and cocaine-treated rats. The likelihood of DA transients increased during the initiation of lever pressing and decreased in the postpress period (quadratic effect of time bin: F_{9, 153}=44.12, p<0.001). A significant cue type × quadratic effect of time bin was also detected (F_{9, 153}=4.50, p<0.001), indicating that the temporal correlation was more pronounced during CS+ trials, although significant quadratic time bin effects were observed for trials with the CS+ (F_{9, 153}=28.97, p<0.001) and the CS− (F_{9, 153}=15.27, p<0.001). No other effect or interaction was significant. See Supplementary Figure S6 for further peri-response frequency distribution analysis.