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. 2014 May 28;39(10):2473–2484. doi: 10.1038/npp.2014.99

Figure 2.

Figure 2

PFC GABA transmission regulates acquisition and expression of discriminative fear conditioning. Graphs depict average suppression (across four CS presentations) for animals receiving (a, b) pre-conditioning or (c, d) pre-test infusion on a discriminative fear conditioning task. Error bars represents +SEM. (a) Saline-infused animals displayed elevated fear to the CS+ and decreased fear to the CS–. However, animals receiving bicuculline infusions before conditioning did not display such discrimination, instead showing elevated fear to a CS– and decreased fear to a CS+ relative to controls. (b) Saline-infused animals showed discrimination across all four CS–/CS+ tones (open circles), while pre-conditioning GABA-blockade animals did not (black squares). (c) Intra mPFC infusions of bicuculline before the discriminative fear test also abolished discrimination between the CS+ and CS–. (d) Saline-infused animals showed discrimination across all four CS–/CS+ tones (open circles), while pre-test GABA-blockade animals did not (black squares). Black star denotes p<0.05 as compared with CS–. #Denotes p<0.05 between CS– for saline and pre-conditioning GABA-blockade. *Denotes p<0.05 vs saline.