Figure 4.

Reducing PFC GABA transmission during fear conditioning enhances expression of learned fear. All error bars reflect +SEM. (a) In rats that were preexposed to the CS without shocks, there were no differences in conditioned suppression between the three groups. (b) In contrast, in non-preexposed rats, intra-mPFC bicuculline before conditioning (black squares) resulted in elevated fear expression across four tones as compared with control animals (open circles) or pre-test bicuculline (gray triangle) infused animals. Star denotes p<0.05 pre-conditioning bicuculline vs the other groups.