Table 1.
Adenosine A2A receptor ligands used in brain ischemia “in vivo” and “in vitro” models.
| Brain ischemia model | References | |
|---|---|---|
| Adenosine A2A receptor agonists | ||
| CGS21680 | Global ischemia in rat | [44] |
| Global ischemia in gerbil | [45] | |
| Focal ischemia in rat | [46] | |
| OGD hippocampal slices | [47, 48] | |
| APEC | Global ischemia in gerbil | [49] |
| Adenosine A2A receptor antagonists | ||
| CGS15943 | Global ischemia in gerbil | [50] |
| Global ischemia in rat | [51] | |
| CSC | Global ischemia in gerbil | [49, 52] |
| Focal ischemia in hypertensive rat | [53] | |
| CP66713 | Global ischemia in gerbil | [52] |
| ZM241385 | Global ischemia in rat | [54] |
| OGD hippocampal slices | [55, 56] | |
| SCH58261 | Hypoxia/ischemia in neonatal rat | [57] |
| Focal ischemia in rat | [58–62] | |
| Global ischemia in newborn piglet | [63] | |
| OGD hippocampal slices | [55, 64] | |
| OGD cerebrocortical slices | [65, 66] | |
| DMPX | OGD hippocampal slices | [48] |
APEC: 2-[(2-aminoethylamino)-carbonylethylphenylethylamino]-5′-N-ethylcarboxoamidoadenosine; CGS15943: 9-chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine; CGS21680: 2-p-(2-Carboxyethyl)phenethylamino-5′-N-ethylcarboxamidoadenosine; CP66713: 4-amino[1,2,4]triazolo[4,3a]quinoxalines; CSC: 8-(3-chlorostyryl)caffeine; DMPX: 3,7-dimethyl-1-propargylxanthine; OGD: oxygen and glucose deprivation; SCH58261: 7-(2-phenylethyl)-5-amino-2-(2-furyl)-pyrazolo-[4,3-e]-[1,2,4]triazolo[1,5-c]pyrimidine; ZM241385: 4-(2-[7-amino-2-(2-furyl)[1,2,4]triazolo[2,3-a][1,3,5]triazin-5-yl-amino]ethyl)phenol.