Table 2.
Bivariate association between apoE ε4 allele and MCI.
| Total (n = 924) | MCI | P value | |
|---|---|---|---|
| NO (N = 743) | Yes (N = 181) | ||
| Allele frequency, n (%) | |||
| ε2 | 139 (9.4) | 24 (6.6) | <0.001 |
| ε3 | 1299 (87.4) | 311 (85.9) | |
| ε4 | 48 (3.2) | 27 (7.5) | |
| ε2 carrier, yes, n (%) | 123 (16.6) | 21 (11.6) | 0.100 |
| ε4 carrier, yes, n (%) | 42 (5.7) | 26 (14.4) | <0.001 |
| Risk index, mean (SD) | 0.1 (0.5) | −0.0 (0.5) | 0.002 |
|
| |||
| Hui (n = 306) | NO (N = 240) | Yes (N = 66) | |
|
| |||
| Allele frequency, n (%) | |||
| ε2 | 46 (9.6) | 11 (8.3) | <0.001 |
| ε3 | 418 (87.1) | 110 (83.3) | |
| ε4 | 16 (3.3) | 11 (8.3) | |
| ε2 carrier, yes, n (%) | 39 (16.25) | 10 (15.1) | 0.829 |
| ε4 carrier, yes, n (%) | 13 (5.4) | 10 (15.1) | 0.008 |
| Risk index, mean (SD) | 0.1 (0.5) | 0.0 (0.6) | 0.118 |
|
| |||
| Han (n = 618) | NO (N = 503) | Yes (N = 115) | |
|
| |||
| Allele frequency (%) | |||
| ε2 | 93 (9.2) | 13 (5.7) | <0.001 |
| ε3 | 881 (87.6) | 201 (87.4) | |
| ε4 | 32 (3.2) | 16 (7.0) | |
| ε2 carrier, yes, n (%) | 84 (16.6) | 11 (9.5) | 0.056 |
| ε4 carrier, yes, n (%) | 29 (5.7) | 16 (13.9) | 0.002 |
| Risk index, mean (SD) | 0.1 (0.5) | 0.0 (0.5) | 0.007 |