Table 4.
Pharmacokinetic parameters derived from PK model of curcumin conjugates: Area Under the Curve (AUC); peak concentration (Cmax); time of peak concentration (tmax); half life (t1/2 ); absorption constant (ka); excretion constant (ke); bioavailability/volume (v); absorption lag (lag ). The mean±standard error of the estimate, 95% confidence intervals for the parameter estimates and 95% prediction intervals for the population are presented.
| Mean±S.E. | 95% Confidence Interval | 95% Prediction Interval | |
|---|---|---|---|
| AUC (μg·hr/ml) 10 gm dose | 35.33±3.78 | (26.90,43.75) | (10.62,117.01) |
| AUC (μg·hr/ml) 12 gm dose | 26.57±2.97 | (19.96,33.18) | (7.86,89.46) |
| Cmax (μg/ml) 10 gm dose | 2.30±0.26 | (1.72,2.88) | (0.71,7.04) |
| Cmax (μg/ml) 12 gm dose | 1.73±0.19 | (1.30,2.16) | (0.52,5.41) |
| tmax (hr) | 3.29±0.43 | (2.34,4.24) | (1.56,7.37) |
| t1/2 (hr) | 6.77±0.83 | (4.82,8.71) | (3.19,14.46) |
| ka(hr−1) | 1.05±0.26 | (0.47,1.64)) | n.a. |
| ke (hr−1) | 0.08±0.0050 | (0.069,0.091) | n.a. |
| v | 3.54±0.41 | (2.63,4.46) | n.a. |
| lag (hr) | 0.68±0.016 | (0.64,0.71) | n.a. |
| dose (gm) | −2.48±0.98 | (−4.66,−0.30) | n.a. |