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. Author manuscript; available in PMC: 2014 Nov 22.
Published in final edited form as: Nature. 2014 Apr 9;509(7501):492–496. doi: 10.1038/nature13180

Extended Data Figure 8. Detection of Cre-mediated recombination and weight measurements of AdCre-treated Ctr1+/+ versus Ctr1flox/flox BP mice.

Extended Data Figure 8

a, PCR detection of BRafCA/+,Trp53flox/flox, and Ctr1flox/flox recombinated alleles from matched tail samples (T) and lung tumor cell lines (C) generated from indicated genotypes. Alleles are indicated by: WT (black), flox (red), null (blue), BrafCA (orange) or BrafV600E (green) arrowheads. b, Box and whiskers plot of weight (grams) of Ctr1+/+ versus Ctr1flox/flox BP mice (n=30) one month after intranasal AdCre treatment. ****P<0.0001.