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DLTs Summary
| Dose Level | No. of Patients Entered | No. of Patients Evaluable | No. of Patients with DLT | DLT Detail (n) |
|---|---|---|---|---|
| 230 mg/m2 Vorinostat and 150 mg/m2 Temozolomide | 6 | 6 | 0 | |
| 300 mg/m2 Vorinostat and 150 mg/m2 Temozolomide | 7 | 6 | 0 | |
| 300 mg/m2 Vorinostat and 200 mg/m2 Temozolomide | 6 | 6 | 4 | Neutropenia (3) Thrombocytopenia (4) Leucopenia (1) |
DLT – Dose limiting toxicity
