Table 1.
Gene transcription data for gfap (glial fibrillary acidic protein; log2(fold-change), p value), a marker of astrocyte activation and neuroinflammation, as measured by microarray. Transcriptional changes are shown for animals exposed to domoic acid relative to the time-matched vehicle controls. Note that all array probes for this gene are non-significant, highlighting the absence of gross neuroinflammation and corroborating the histopathological assessment presented in Figure 1.
| NCBI GenBank ID | Probe ID |
gfap Log2(fold-change) (p value)
|
|||||
|---|---|---|---|---|---|---|---|
| 2 weeks | 6 weeks | 12 weeks | 18 weeks | 24 weeks | 36 weeks | ||
| NM_131373 | A_15_P107505 | 0.33 (0.19) | 0.02 (0.93) | 0.14 (0.56) | 0.45 (0.07) | 0.13 (0.59) | −0.14 (0.57) |
| NM_131373 | A_15_P131871 | 0.02 (0.77) | −0.03 (0.65) | 0.03 (0.64) | 0.05 (0.47) | −0.03 (0.67) | −0.07 (0.30) |
| AY397679 | A_15_P551122 | 0.00 (0.90) | 0.01 (0.78) | −0.01 (0.71) | −0.02 (0.30) | 0.00 (0.88) | −0.01 (0.62) |
| NM_131373 | A_15_P658936 | 0.05 (0.57) | −0.01 (0.91) | 0.04 (0.59) | 0.19 (0.02) | 0.03 (0.73) | −0.05 (0.55) |