In vivo efficacy of MVBMOG/PLP in suppressing PLP-induced EAE. MVBMOG/PLP-treated mice (n = 6) received three s.c. injections at a concentration of 100 nmol/100 μl on days 4, 7, and 10 and its efficacy was compared to that of PBS in mice (n = 6) treated in a similar fashion. Progress of the disease was monitored following (A) the clinical disease score, expressed as the mean clinical score ± SEM, and (B) the percent change in body weight, expressed as the mean % change in body weight ± SEM.