Table 2. Summary of in vivo studies.

Groupa	Induction antigen	Incidence of diseaseb	Mean maximal score ± SEM
In vivo Study I
PBS	MOG	6/6	4.00 ± 0.18
PLP-BPI	MOG	6/6	3.00 ± 0.47
MOG-BPI	MOG	6/6	2.25 ± 0.46
PBS	PLP	6/6	1.67 ± 0.59
MOG-BPI	PLP	6/6	1.50 ± 0.53
In vivo Study II
PBS	MOG	12/12	3.58 ± 0.24
MOG	MOG	5/6	2.42 ± 0.52
MOG-BPI	MOG	5/5	2.20 ± 0.31
MVBMOG/PLP	MOG	4/12	0.88 ± 0.49
In vivo Study III
PBS	PLP	6/6	1.67 ± 0.59
MVBMOG/PLP	PLP	3/6	0.58 ± 0.27

^aAll injections were administered s.c. at 100 nmol (100 μl PBS) on days 4, 7, and 10.

^bIncidence of disease was defined as a disease score of 1 or higher.