Table 4. Association of BMI¹ and age² with prognostic relevant breast cancer characteristics (15).

	95% CI (entire cohort)	P value	95% CI (postmenopausal women)	P value
Beta-coefficient
Tumor size (all patients)
BMI	0.03 (0.01-0.05)	<0.001	0.03 (0.01-0.05)	0.002
Age	0.01 (0-0.02)	0.082	0.01 (0.02-0.05)	<0.001
Tumor size (tumor detected by self-examination)
BMI	0.05 (0.03-0.07)	<0.001	0.04 (0.02-0.06)	<0.001
Age	0.001 (0-0.02)	0.188	0.01 (–0.01-0.03)	0.349
Tumor size (tumor detected by mammography or sonography)
BMI	0.03 (0-0.07)	0.044	0.03 (0.0-0.07)	0.076
Age	0 (–0.03-0.03)	0.84	0.02 (–0.03-0.06)	0.457
OR
TNM stage (III/IV vs. I/II)
BMI	1.16 (1.02-1.31)	0.022	1.06 (0.92-1.23)	0.402
Age	0.97 (0.89-1.06)	0.525	1.01 (0.88-1.17)	0.833
Histological type (lobular vs. ductal)
BMI	1.04 (0.89-1.22)	0.602	1.05 (0.89-1.25)	0.573
Age	1.18 (1.06-1.32)	0.003	1.09 (0.92-1.28)	0.324
Grading (3 vs. 1 and 2)
BMI	1.11 (1.00-1.25)	0.057	1.10 (0.97-1.2)	0.135
Age	0.91 (0.84-0.98)	0.019	0.91 (0.81-1.03)	0.151
ER status (positive vs. negative)
BMI	0.95 (0.83-1.09)	0.459	0.99 (0.84-1.16)	0.874
Age	1.23 (1.11-1.35)	<0.001	1.20 (1.02-1.40)	0.025
HER2 status (positive vs. negative)
BMI	0.92 (0.74-1.15)	0.467	0.92 (0.72-1.18)	0.526
Age	0.95 (0.82-1.10)	0.495	0.97 (0.77-1.22)	0.786
Triple negativity (yes vs. no)
BMI	1.19 (0.93-1.52)	0.165	0.87 (0.64-1.17)	0.35
Age	0.71 (0.59-0.86)	<0.001	1.35 (0.99-1.84)	0.052
St. Gallen risk score (high vs. low)
BMI	1.24 (1.00-1.55)	0.049	1.20 (0.94-1.53)	0.154
Age	0.88 (0.75-1.02)	0.091	0.89 (0.70-1.12)	0.308

BMI, body mass index; ER, estrogen receptor; CI, confidence interval; OR, odds ratio; ¹, per 5 BMI unit; ², per 10 years.