FIGURE 6.

Intracellular amphetamine and methamphetamine elicit similar DAT-mediated current. A, the schematic depicts the experimental configuration. The CHO-YFP-DAT cells were patch-clamped in whole-cell configuration. Amphetamine (10 μm; n = 5) or methamphetamine (10 μm; n = 5) was dialyzed into the cell via the patch pipette. B, the bar graph compares the DAT-mediated inward current at −100 mV and −80 mV after intracellular delivery of the drugs. There is no difference between amphetamine- or methamphetamine-induced DAT-mediated inward currents at the examined membrane potentials.