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. 2014 Jun 24;289(32):22246–22257. doi: 10.1074/jbc.M114.563056

FIGURE 8.

FIGURE 8.

Removal of extracellular Cl− preferentially blocks amphetamine-induced DAT-mediated current relative to methamphetamine. A and B, bar graphs show the amphetamine- or methamphetamine-induced DAT current at −100 mV after removal of Cl− ions in the external solution. C, substitution of Cl− ions in the external solution blocks 70.16 ± 2.0% of amphetamine-induced DAT current but only 42.44 ± 2.4% of methamphetamine-induced current. D and E, bar graphs show amphetamine- or methamphetamine-induced inward current at −100 mV upon removal of Na+ ions in the external solution. F, substitution of Na+ ions in the external solution equally blocks the amphetamine- and methamphetamine-induced DAT currents (*; p < 0.05).