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. 2014 Jun 24;289(32):22246–22257. doi: 10.1074/jbc.M114.563056

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 9. — Side by side comparison of the effects of amphetamine versus methamphetamine-induced DAT-mediated inward currents. The bar graph shows a side by side comparison of the effects of amphetamine versus methamphetamine-induced DAT-mediated inward currents at (−100 mV holding potential) at two different concentrations of extracellular chloride ions (Cl⁻). We observed that at 0 mm Cl⁻ ion concentration the inward current induced by amphetamine was significantly blocked and to a higher extent compared with methamphetamine, whereas at 131.5 mm extracellular Cl⁻ ion concentration amphetamine produced significantly higher inward current compared with methamphetamine.