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. 2014 Aug 20;9(8):e104925. doi: 10.1371/journal.pone.0104925

Table 1. Pathway analysis of liver transcriptome in SHIVA mouse.

KEGG entry pathway name p-value
Downregulated pathways in SHIVA mouse
mmu00071 Fatty acid metabolism 0
mmu00590 Arachidonic acid metabolism 0
mmu00830 Retinol metabolism 0
mmu01040 Biosynthesis of unsaturated fatty acids 0
mmu03320 PPAR signaling pathway 0
mmu00120 Primary bile acid biosynthesis 0.004
mmu00770 Pantothenate and CoA biosynthesis 0.008
mmu00561 Glycerolipid metabolism 0.02
mmu00982 Drug metabolism - cytochrome P450 0.027
mmu00930 Caprolactam degradation 0.039
mmu00100 Steroid biosynthesis 0.04
mmu00900 Terpenoid backbone biosynthesis 0.041
mmu00061 Fatty acid biosynthesis 0.042
Upregulated pathways in SHIVA mouse
mmu00250 Alanine, aspartate and glutamate metabolism 0.001
mmu04640 Hematopoietic cell lineage 0.001
mmu04610 Complement and coagulation cascades 0.002
mmu00052 Galactose metabolism 0.004
mmu04612 Antigen processing and presentation 0.004
mmu04662 B cell receptor signaling pathway 0.004
mmu00010 Glycolysis/Gluconeogenesis 0.007
mmu00053 Ascorbate and aldarate metabolism 0.007
mmu00561 Glycerolipid metabolism 0.007
mmu00340 Histidine metabolism 0.008
mmu00620 Pyruvate metabolism 0.008
mmu00910 Nitrogen metabolism 0.008
mmu04630 Jak-STAT signaling pathway 0.008
mmu04910 Insulin signaling pathway 0.008
mmu00140 C21-Steroid hormone metabolism 0.009
mmu00410 beta-Alanine metabolism 0.009
mmu04620 Toll-like receptor signaling pathway 0.009
mmu04920 Adipocytokine signaling pathway 0.009
mmu00330 Arginine and proline metabolism 0.01
mmu00380 Tryptophan metabolism 0.01
mmu00480 Glutathione metabolism 0.01
mmu00720 Reductive carboxylate cycle (CO2) 0.01
mmu00310 Lysine degradation 0.013
mmu00982 Drug metabolism - cytochrome P450 0.016