Mitochondrial proteins (a) MnSOD and (b) UCP3 after 8-day exercise intervention in (i) SD, (ii) SHHF lean and (iii) SHHF obese rats. Exercise-induced increases in the CREB-dependent mitochondrial antioxidant proteins (a) MnSOD and (b) UCP3 in the SHHF lean rats only. SD (sedentary: n = 8/4, exercise: n = 10/4), SHHF lean (sedentary: n = 8/9, exercise: n = 10/9), SHHF obese (sedentary: n = 9, exercise: n = 9). Data are expressed as mean fold change from sedentary groups + SEM. *p < 0.05, †p = 0.1, Student’s t-test.
SD: Sprague Dawleys; MnSOD: manganese superoxide dismutase; CREB: cyclic adenosine monophosphate response element binding protein; UCP3: uncoupling protein 3; SEM: standard error of mean.