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. 2014 Aug 20;9(8):e104763. doi: 10.1371/journal.pone.0104763

Figure 3. Miglustat and Genz-529648 inhibit GBA2 activity in IB3-1 and CuFi-1 cells infected by P. aeruginosa.

Figure 3

IB3-1 and CuFi-1 cells were treated with [2 µM] miglustat, [10 nM] Genz-529648 or solvent alone for 1 hour prior to infection with heat-killed PAO1 for 4 hours. Total β–glucosidase (A), GBA1 (B) and GBA2 (C) activities were measured as indicated in figure 2. The data reported are the mean ± standard error of the mean of 3 (IB3-1) or 2 (CuFi-1) independent experiments in triplicate. Comparisons between groups were made by using Student’s t tests.