Figure 1. Virtual screening by docking.

A. Heat map analysis of binding constants of 140 FDA approved nervous system drugs screened against Aβ, AChE and β-secretase by Autodock tool 4.2. In the gradient ruler, red colour indicated strong binding (ΔG<−6 kcal/mol), while green colour indicate weak binding (ΔG>−3 kcal/mol) and the five drugs showing higher affinity to all the above mentioned targets were zoomed. B. Chemical structures of the five drugs. All are tricyclic anti-depressant drugs.