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. 2014 Aug 20;9(8):e105222. doi: 10.1371/journal.pone.0105222

Figure 2. Correlation of PK parameters (Cmax, AUC) with in vivo efficacy in mice for bicyclic 4-nitroimidazole analogs in total plasma concentration (A), free plasma concentration (B) and total lung concentration (C).

Figure 2

Each data point represents Δ mean log lung CFU reduction compared to untreated controls (mean value ± SEM from 5 animals). rs is the Spearman’s rank correlations coefficient.