Figure 4. Distribution of UVA1 modulated genes in functional families.

In order to perform an exhaustive bibliographic analysis including literature related to skin and dermatology, the list of UVA1 modulated genes was reduced by using a fold change threshold>2 or <0.5, and an Adjp<0.001. Under these criteria, 134 and 141 genes were found modulated in fibroblasts and keratinocytes respectively of UVA1 exposed reconstructed skins. In fibroblasts 24 genes out of 134 could not be classified because their functions were poorly described; 110 genes were distributed in functional families (A). In keratinocytes 30/141 genes could not be classified; 111 genes were distributed in functional families (B). Some genes could be classified in several functional families. Lists of gene names associated with gene bank accession number, fold change values and their distribution in functional families are given in Tables S6 and S7, for fibroblasts and keratinocytes respectively.