Table 1. Summary of most significant enriched GO Biological Process terms in reconstructed skins exposed to UVA1.
Number of GO terms | Pvalue min | Pvalue max | |
Up-regulated probe sets in fibroblasts | |||
Response to stimulus | 19 | 2.4e-12 | 2.7e-07 |
Cell death/Apoptosis | 11 | 5.9e-12 | 2.5e-07 |
Signaling | 12 | 3.9e-10 | 2.9e-07 |
Protein modification | 3 | 1.3e-08 | 1.7e-07 |
Cell communication | 2 | 9.8e-08 | 2.7e-07 |
Regulation of metabolic process/biological process | 4 | 1.0e-07 | 1.8e-07 |
Down-regulated probe sets in fibroblasts | |||
Response to virus | 5 | 8.1e-12 | 3.2e-11 |
Response to cytokine/Innate immunity | 4 | 9.8e-08 | 5.6e-07 |
Development/Morphogenesis | 28 | 3.3e-09 | 1.3e-05 |
Cell migration/Motility | 6 | 3.2e-08 | 2.9e-06 |
Signaling | 2 | 7.6e-07 | 2.2e-06 |
Response to stimulus | 5 | 7.8e-07 | 4.4e-06 |
Up-regulated probe sets in keratinocytes | |||
Response to stimulus | 21 | 2.3e-11 | 7.8e-06 |
Signaling | 13 | 4.6e-09 | 4.2e-06 |
Cell communication | 3 | 3.8e-08 | 1.1e-06 |
Cell death/Apoptosis | 4 | 6.0e-07 | 6.7e-06 |
Glucose metabolism | 3 | 3.2e-07 | 3.8e-06 |
Phosphate metabolism | 2 | 1.9e-06 | 3.6e-06 |
Protein metabolism | 2 | 3.4e-06 | 7.4e-06 |
Development | 1 | 9.2e-07 | 9.2e-07 |
Oxidative stress response | 1 | 5.2e-06 | 5.2e-06 |
Down-regulated probe sets in keratinocytes | |||
Lipid metabolism | 24 | 1.9e-06 | 0.0033 |
Response to virus | 13 | 4.9e-06 | 0.0034 |
Metabolic process | 6 | 0.00012 | 0.0014 |
Cell migration | 2 | 0.0028 | 0.0028 |
Response to stress | 2 | 0.0028 | 0.0033 |
Miscellanous | 3 | 0.00017 | 0.0024 |
Summary of the list of the top 50 enriched GO terms related to Biological Process (BP) for the up-regulated probe sets and down-regulated probe sets in fibroblasts and keratinocytes of reconstructed skins exposed to UVA1. The detailed lists are given in Tables S2 and S3, for fibroblasts and keratinocytes, respectively.