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. 2014 Aug 20;9(8):e105520. doi: 10.1371/journal.pone.0105520

Figure 4. Challenge with P.berghei sporozoites.

Figure 4

Balb/c mice (6 mice per group) were immunised i.m. with two different doses of HAdV5.TIP-EGFP or HAdV5.TIP-EGFP_m4-1BBL and challenged with 1000 P.berghei sporozoites 2 weeks later. The response to Pb9 in the blood was measured 2 days prior to challenge by IFN-γ ELISpot. A) The bar represent the median with each individual animal displayed as a single point. Data was analysed with a 2-way analysis of variance a post-hoc Bonferroni test; the p value denotes the level of statistical significance. B) Parasitaemia was measured daily and the time to 0.5% parasitaemia calculated by linear regression. Survival curves were compared with a log-rank (Mantel-Cox) test but no significant difference between groups was observed.