Table III.

Hazard ratios for CHD or all-cause mortality by CKD and diabetes status, MetSyn, and cigarette smoking analyzed separately

	No CKD		CKD
	No DM (n = 2001)	DM (n = 627)	No DM (n = 742)	DM (n = 568)
Recurrent CHD events
Model 1	1 (ref)	1.45 (1.05–2.00)	1.90 (1.44–2.51)	2.65 (2.01–3.50)
Model 2	1 (ref)	1.30 (0.92–1.84)	1.59 (1.18–2.13)	2.07 (1.51–2.83)
All-cause mortality
Model 1	1 (ref)	1.03 (0.78–1.37)	1.85 (1.50–2.28)	2.72 (2.20–3.35)
Model 2	1 (ref)	0.96 (0.71–1.31)	1.43 (1.14–1.79)	2.14 (1.69–2.71)
Pooled outcome—Recurrent CHD events or all-cause mortality
Model 1	1 (ref)	1.19 (0.94–1.50)	1.91 (1.59 – 2.29)	2.65 (2.20–3.19)
Model 2	1 (ref)	1.11 (0.86–1.43)	1.54 (1.26–1.87)	2.08 (1.68–2.57)
	No MetSyn (n = 1419)	MetSyn (n = 1209)	No MetSyn (n = 530)	MetSyn (n = 780)
Recurrent CHD events
Model 1	1 (ref)	1.44 (1.07–1.94)	2.29 (1.65–3.17)	2.55 (1.91–3.41)
Model 2	1 (ref)	1.19 (0.85–1.66)	1.88 (1.34–2.64)	1.77 (1.27–2.48)
All-cause mortality
Model 1	1 (ref)	1.07 (0.84–1.36)	2.01 (1.58–2.56)	2.42 (1.95–3.00)
Model 2	1 (ref)	0.94 (0.72–1.23)	1.46 (1.13–1.90)	1.84 (1.43–2.37)
Pooled outcome—recurrent CHD events or all-cause mortality
Model 1	1 (ref)	1.22 (0.99–1.50)	2.23 (1.80–2.75)	2.39 (1.97–2.90)
Model 2	1 (ref)	1.10 (0.87–1.39)	1.72 (1.38–2.16)	1.83 (1.46–2.30)
	Not smoking (n = 2240)	Current smoking (n = 388)	Not smoking (n = 1094)	Current smoking (n = 216)
Recurrent CHD events
Model 1	1 (ref)	2.25 (1.57–3.22)	2.11 (1.66–2.68)	3.61 (2.47–5.27)
Model 2	1 (ref)	2.08 (1.42–3.06)	1.75 (1.35–2.27)	2.58 (1.70–3.92)
All-cause mortality
Model 1	1 (ref)	2.67 (2.00–3.57)	2.30 (1.91–2.76)	3.94 (2.95–5.27)
Model 2	1 (ref)	2.06 (1.51–2.81)	1.84 (1.51–2.26)	2.56 (1.86–3.52)
Pooled outcome—recurrent CHD events or all-cause mortality
Model 1	1 (ref)	2.58 (2.01–3.31)	2.20 (1.87–2.59)	4.04 (3.14–5.19)
Model 2	1 (ref)	2.09 (1.60–2.72)	1.81 (1.52–2.16)	2.62 (1.98–3.46)

Numbers in table are HR (95% CI). Models 1 and 2 adjusted as stated in Table II. DM, Diabetes mellitus.