Table 3. HLA-B27 transgenic animals have significant alterations in gut microbiota by 16s rDNA sequencing.
| Animal group comparison | Permanova analysis, p value | n from each group | |
| Co-housed animals | Whole cecum (WT vs B27/B2M)* | 1.9066, 0.006 | 6 vs 7 |
| Cecal mucosa (WT vs B27/B2M) | 1.2121, 0.1688 | 6 vs 6 | |
| Cecal lumen (WT vs B27/B2M) | 1.0113, 0.4266 | 6 vs 6 | |
| Non-co-housed animals | Cecal lumen (WT vs B27/B2M vs B2M)* | 3.4031, 0.001 | 7 vs 8 vs 7 |
| Cecal lumen (WT vs B27/B2M)* | 4.7903, 0.001 | 7 vs 8 | |
| Cecal lumen (WT vs B2M)* | 5.1028, 0.001 | 7 vs 7 | |
| Cecal lumen (B27/B2M vs B2M) | 0.76438, 0.7652 | 8 vs 7 | |
| Cecal mucosa (WT vs B27/B2M vs B2M)* | 2.4418, 0.001 | 7 vs 8 vs 7 | |
| Cecal mucosa (WT vs B27/B2M)* | 3.1632, 0.002 | 7 vs 8 | |
| Cecal mucosa (WT vs B2M)* | 3.0912, 0.001 | 7 vs 7 | |
| Cecal mucosa (B27/B2M vs B2M) | 1.0951, 0.3017 | 8 vs 7 |
WT: wild-type Lewis rats; B27/B2M: (21–3×283–2)F1 HLA-B27/hβ2m transgenic Lewis rats; B2M: 283–2 hβ2m expressing transgenic rats; * designates p<0.05.