Table 1. Properties of HBMC membrane proteins significantly expressed or repressed upon TNF-α exposure in comparison to non-treated cells.
| Ratioa | Gene name | MWb | pI | Cysteinec | P valued | Mascot scoree |
|---|---|---|---|---|---|---|
| 1.91 | Unnamed protein product | 24.7 | 8.66 | 3 | 3.20E−06 | 129 |
| Arginine-rich protein-human | 26.9 | 10.08 | 9 | 3.20E−06 | 51 | |
| Reticulon 3 isoform a | 25.6 | 8.67 | 3 | 3.20E−06 | 36 | |
| Reticulon 1 isoform A | 83.6 | 4.62 | 5 | 3.20E−06 | 36 | |
| Hypothetical protein | 66.3 | 7.68 | 10 | 3.20E−06 | 36 | |
| 1.75 | Unnamed protein product | 24.7 | 8.66 | 3 | 1.20E−05 | 91 |
| Enhancer protein | 22.1 | 8.16 | 6 | 1.20E−05 | 88 | |
| 1.74 | Lymphocyte specific 1 isoform 1 | 36.7 | 4.77 | 2 | 0.0043 | 81 |
| 1.7 | Dihydrolipoyl dehydrogenase | 54.1 | 7.59 | 10 | 0.017 | 59 |
| Structure of human glutamate dehydronase (Chain A) | 56.0 | 6.71 | 6 | 0.017 | 55 | |
| Glutamate dehydrogenase 1 variant | 61.3 | 8.05 | 6 | 0.017 | 51 | |
| 1.64 | Tyrosin3/tryptophan 5-mono-oxygenase activation protein | 29.3 | 4.63 | 2 | 0.0057 | 7 |
| Light polypeptide isoform a (Clathrin) | 23.2 | 4.63 | 2 | 0.0057 | 45 | |
| 1.62 | Manganese superoxidedismutase | 24.7 | 8.35 | 3 | 9.50E−05 | 49 |
| Enhancer protein | 22.1 | 8.16 | 6 | 9.50E−05 | 39 | |
| Ring finger protein 148 | 34.4 | 8.49 | 8 | 9.50E−05 | 34 | |
| 1.58 | Heterogeneous nuclear ribonucleo-protein A/B isoform a | 35.9 | 6.49 | 2 | 0.0037 | 84 |
| Protein tyrosin kinase | 40.3 | 6.48 | 3 | 0.0037 | 83 | |
| Ubiquitin fusion degradation1-like isoform A | 34.5 | 6.27 | 5 | 0.0037 | 70 | |
| Translation initiation factor eLF3 p40 40subunit eIF3p | 39.9 | 6.38 | 3 | 0.0037 | 69 | |
| Carboxyl terminal LIM domain protein | 36.1 | 6.80 | 8 | 0.0037 | 62 | |
| –1.5 | Hydroxysteroid (17-β) dehydronerase 10 isoform 1 | 26.9 | 7.66 | 4 | 6.90E−05 | 57 |
| Heterogeneous nuclear ribonucleo-protein A2/Ba isoform A2 | 36.0 | 8.67 | 1 | 6.90E−05 | 55 | |
| TPI1 protein | 27.4 | 8.48 | 6 | 6.90E−05 | 47 | |
| Triosephosphate isomerase (TIM) | 26.6 | 7.10 | 5 | 6.90E−05 | 46 | |
| –1.52 | Neuroleukin | 63.1 | 8.43 | 4 | 0.009 | 84 |
| Chaperonin containing TCP1, subunit 7 isoform a | 59.3 | 7.55 | 9 | 0.009 | 39 | |
| –1.55 | Unknown | 28.3 | 8.59 | 3 | 5.20E−05 | 46 |
| –1.63 | Heterongeneous nuclear ribonucleo-protein A1 | 38.8 | 9.26 | 2 | 5.20E−05 | 56 |
| –1.68 | Unknown | 28.3 | 8.59 | 3 | 0.0029 | 46 |
| Ribosomal protein small subunit structure of the karyopherin beta2-ran gppnhp | 30.0 | 9.75 | 4 | 0.0029 | 37 | |
| Nuclear transport complex (Chain C) | 24.3 | 7.01 | 3 | 0.0029 | 34 | |
| –1.72 | Cell cycle proteinp38–2G4 homolog | 43.8 | 6.13 | 6 | 0.0084 | 38 |
| –1.8 | Moesin | 67.8 | 6.08 | 2 | 0.0058 | 62 |
| ESP-2 (zyxin) | 53.1 | 5.89 | 21 | 0.0058 | 41 | |
| –1.83 | Adenylate kinase 2 isoform a | 26.5 | 7.67 | 4 | 0.0088 | 59 |
| High-mobility group box 2 | 24.0 | 7.62 | 3 | 0.0088 | 48 | |
| –1.84 | Heterogeneous nuclear ribonucleo-protein A1 | 38.8 | 9.26 | 2 | 0.00076 | 53 |
| Dermcidin preproprotein | 11.3 | 6.08 | 2 | 0.00076 | 40 | |
| Heterogeneous nuclear ribonucleo-protein A2/B1 isoform B1 | 37.4 | 8.91 | 1 | 0.00076 | 35 |
a Relative protein abundance TNF-α treated cells: non-treated cells; bMolecular weight; cNumber of cysteine residues (or is this number of predicted cysteine residues?); dP value (X test); eMascot score derived using Y method.