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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Nat Immunol. 2014 Jul 27;15(9):839–845. doi: 10.1038/ni.2948

Figure 5. Differential role of SKIV2L and TTC37 in RLR regulation.

Figure 5

(a) Immunoblots of primary BMDM lysates showing TTC37 protein expression in knockdown and control cells. Data are representative of two independent experiments.

(b,c) Cells were transduced with the indicated lentiviral shRNA constructs and treated with thapsigarin or RIG-I ligands and assessed for IFN-β production by quantitative RT-PCR. RIG-I ligand-treated samples were harvested at 4 h and thapsigargin-treated samples were harvested at 2 h. *P < 0.01; **P < 0.005; ***P < 0.0001; (one-way ANOVA, b–c). Data are representative of two independent experiments with biological triplicates (mean + s.d., b–c).