Table 3.
Neuropathological data (mean score ± SD or % prevalence, unless otherwise specified) by clinical diagnosis
| Retrospective Clinical diagnosis at time of autopsy | |||
|---|---|---|---|
| No dementia (n=29)* |
Dementia (n=30)* | P | |
| Brain weight, grams | 1297.9 ± 170.2 | 1152.3 ± 163.4 | 0.002 |
| Total NFT score** | 10.9 ± 7.6 | 25.8 ± 14.4 | <0.001 |
| Cortical NFT score** | 2.9 ± 4.1 | 11.4 ± 8.6 | <0.001 |
| MTL NFT score** | 4.3 ± 2.1 | 7.3 ± 3.6 | <0.001 |
| Braak NFT stage | 2.1 ± 1.4 | 3.8± 1.8 | 0.001 |
| Total NP score** | 7.1 ± 7.6 | 15.7 ± 11.1 | 0.001 |
| Cortical NP score** | 4.9 ± 5.1 | 10.4 ± 7.2 | 0.001 |
| MTL NP score** | 2.2 ± 2.9 | 5.3 ± 4.4 | 0.002 |
| CERAD NP score | 3.0 ± 0.9 | 2.2 ± 1.1 | 0.006 |
| Atherosclerosis score | 2.3 ± 3.0 | 3.5 ± 3.8 | 0.185 |
| Ischemic Injury Score (IIS) | 4.6 ± 4.0 | 5.7 ± 3.8 | 0.288 |
| Vascular Injury Score (VIS) | 3.8 ± 3.1 | 4.1 ± 3.5 | 0.752 |
| Amyloid angiopathy score | 0.4 ± 0.6 | 0.6 ± 0.6 | 0.158 |
| Subjects with chronic infarcts (N) | 4 | 7 | --- |
| Subjects with chronic lacunes | 4 | 7 | --- |
| Total microinfarct score | 2.7 ± 3.6 | 1.8 ± 3.0 | 0.303 |
| Prevalence of microinfarcts (%) | 58.6 | 43.3 | 0.240 |
|
Prevalence of hippocampal sclerosis (%) |
6.9 | 20.0 | <0.001 |
Abbreviations: NFT, neurofibrillary tangle; MTL, medial temporal lobe; NP, neuritic plaque; CERAD, Consortium to Establish a Registry for Alzheimer's Disease
*
Refers to diagnosis at the time of death based on retrospective CDR.17
**
Refers to the tabulated summary scoring of NFT and NP density.